Eliran Mor

 Mounting and robust evidence suggests there are reproductive and pregnancy risks associated with environmental pollutants, workplace teratogens, and endocrine disruptors. By the time a woman presents with pregnancy, disruptions of organogenesis may have already occurred. For these reasons, prepregnancy patient history and identification of exposures are encouraged 74. If exposures are identified, patients can be educated regarding the avoidance of exposure to toxic agents and, when necessary, referred to occupational medicine programs. Exposures can occur both at home (eg, plastics with bisphenol-A, pesticides, lead paint, asbestos) and at work. Employment sectors at particular risk of potentially hazardous exposures during pregnancy include agriculture (pesticides), manufacturing (organic solvents and heavy metals), dry cleaning (solvents), and health care (biologics and radiation) 75. See the For More Information section for additional resources.

 Women should be counseled to seek medical care before attempting to become pregnant or as soon as they believe they are pregnant to aid in correct dating and to be monitored for any medical conditions in which treatment should be modified during pregnancy. Correct first-trimester pregnancy dating provides value in managing potential subsequent pregnancy complications and indications for delivery.

 The American College of Obstetricians and Gynecologists has identified additional resources on topics related to this document that may be helpful for ob-gyns, other health care providers, and patients. You may view these resources at www.acog.org/More-Info/PrepregnancyCounseling .

 These resources are for information only and are not meant to be comprehensive. Referral to these resources does not imply the American College of Obstetricians and Gynecologists' endorsement of the organization, the organization's website, or the content of the resource. The resources may change without notice.

 Curtis KM , Tepper NK , Jatlaoui TC , Berry-Bibee E , Horton LG , Zapata LB , et al . U.S. medical eligibility criteria for contraceptive use, 2016 . MMWR Recomm Rep 2016 ; 65 : 1 – 104 .

 Curtis KM , Jatlaoui TC , Tepper NK , Zapata LB , Horton LG , Jamieson DJ , et al . U.S. selected practice recommendations for contraceptive use, 2016 . MMWR Recomm Rep 2016 ; 65 : 1 – 66 .

 Quinn MM , Rosen MP , Allen IE , Huddleston HG , Cedars MI , Fujimoto VY . Decreased clinical pregnancy and live birth rates after short interval from delivery to subsequent assisted reproductive treatment cycle . Hum Reprod 2018 ; 33 : 1316 – 21 .

 Alexander EK , Pearce EN , Brent GA , Brown RS , Chen H , Dosiou C , et al . 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum . Thyroid 2017 ; 27 : 315 – 89 .

 Yonkers KA , Wisner KL , Stewart DE , Oberlander TF , Dell DL , Stotland N , et al . The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists . Obstet Gynecol 2009 ; 114 : 703 – 13 .

 Samplaski MK , Loai Y , Wong K , Lo KC , Grober ED , Jarvi KA . Testosterone use in the male infertility population: prescribing patterns and effects on semen and hormonal parameters . Fertil Steril 2014 ; 101 : 64 – 9 .

 American Society for Reproductive Medicine . Choosing wisely: don’t prescribe testosterone or testosterone products to men contemplating/attempting to initiate pregnancy . Philadelphia (PA) : ABIM Foundation ; 2015 . Available at: http://www.choosingwisely.org/clinician-lists/asrm-testosterone-to-initiate-pregnancy . Retrieved August 21, 2018.

 Markowitz LE , Dunne EF , Saraiya M , Chesson HW , Curtis CR , Gee J , et al . Human papillomavirus vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP). Centers for Disease Control and Prevention (CDC) [published erratum appears in MMWR Recomm Rep 2014;63:1182] . MMWR Recomm Rep 2014 ; 63 ( RR-05 ): 1 – 30 .

 Jack BW , Atrash H , Coonrod DV , Moos MK , O'Donnell J , Johnson K . The clinical content of preconception care: an overview and preparation of this supplement . Am J Obstet Gynecol 2008 ; 199 : S266 – 79 .

 Workowski KA , Bolan GA . Sexually transmitted diseases treatment guidelines, 2015. Centers for Disease Control and Prevention [published erratum appears in MMWR Recomm Rep 2015;64:924] . MMWR Recomm Rep 2015 ; 64 ( RR-03 ): 1 – 137 .

 Recommendations for reducing the risk of viral transmission during fertility treatment with the use of autologous gametes: a committee opinion. Practice Committee of American Society for Reproductive Medicine . Fertil Steril 2013 ; 99 : 340 – 6 .

 Cytomegalovirus, parvovirus B19, varicella zoster, and toxoplasmosis in pregnancy. Practice Bulletin No. 151. American College of Obstetricians and Gynecologists [published erratum appears in Obstet Gynecol 2016;127:405] . Obstet Gynecol 2015 ; 125 : 1510 – 25 .

 American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine . Practice advisory interim guidance for care of obstetric patients during a Zika virus outbreak . Washington, DC : ACOG; SMFM , 2018 . Available at: https://www.acog.org/Clinical-Guidance-and-Publications/Practice-Advisories/Practice-Advisory-Interim-Guidance-for-Care-of-Obstetric-Patients-During-a-Zika-Virus-Outbreak . Retrieved September 13, 2018.

 American Society of Reproductive Medicine . Guidance for providers caring for women and men of reproductive age with possible Zika virus exposure . Birmingham (AL) : ASRM ; 2017 . Available at: http://www.asrm.org/globalassets/asrm/asrm-content/news-and-publications/practice-guidelines/for-non-members/guidance_for_providers_zika_virus_exposure.pdf . Retrieved June 20, 2018.

 Panel on treatment of pregnant women with HIV infection and prevention of perinatal transmission. Recommendations for use of antiretroviral drugs in transmission in the United States . Rockville (MD) : Department of Health and Human Services ; 2015 . Available at: https://aidsinfo.nih.gov/contentfiles/lvguidelines/PerinatalGL.pdf . Retrieved June 20, 2018.

Dr Eliran

 Centers for Disease Control and Prevention . U.S. Public Health Service: preexposure prophylaxis for the prevention of HIV infection in the United States – 2017 update. A clinical practice guideline . Atlanta (GA) : CDC ; 2017 . Available at: https://www.cdc.gov/hiv/pdf/risk/prep/cdc-hiv-prep-guidelines-2017.pdf . Retrieved June 20, 2018.

 U.S. Surgeon General . The health consequences of smoking—50 years of progress: a report of the Surgeon General, 2014 . Washington, DC : U.S. Department of Health and Human Services ; 2014 . Available at: https://www.surgeongeneral.gov/library/reports/50-years-of-progress/index.html . Retrieved June 20, 2018.

 McDonald SD , Walker MC , Ohlsson A , Murphy KE , Beyene J , Perkins SL . The effect of tobacco exposure on maternal and fetal thyroid function . Eur J Obstet Gynecol Reprod Biol 2008 ; 140 : 38 – 42 .

 Spinillo A , Nicola S , Piazzi G , Ghazal K , Colonna L , Baltaro F . Epidemiological correlates of preterm premature rupture of membranes . Int J Gynaecol Obstet 1994 ; 47 : 7 – 15 .

 Carson G , Cox LV , Crane J , Croteau P , Graves L , Kluka S , et al . Alcohol use and pregnancy consensus clinical guidelines. Society of Obstetricians and Gynaecologists of Canada . J Obstet Gynaecol Can 2010 ; 32 : S1 – 31 .

 Chamberlain L , Levenson R . Addressing intimate partner violence, reproductive and sexual coercion: a guide for obstetric, gynecologic and reproductive health care settings . 2nd ed . Washington, DC : American College of Obstetricians and Gynecologists ; San Francisco (CA) : Futures Without Violence ; 2012 . Available at: https://www.futureswithoutviolence.org/userfiles/file/HealthCare/reproguidelines_low_res_FINAL.pdf . Retrieved June 20, 2018.

 Frayne DJ , Verbiest S , Chelmow D , Clarke H , Dunlop A , Hosmer J , et al . Health care system measures to advance preconception wellness: consensus recommendations of the clinical workgroup of the National Preconception Health and Health Care Initiative . Obstet Gynecol 2016 ; 127 : 863 – 72 .

 Buck Louis GM , Sapra KJ , Schisterman EF , Lynch CD , Maisog JM , Grantz KL , et al . Lifestyle and pregnancy loss in a contemporary cohort of women recruited before conception: The LIFE Study . Fertil Steril 2016 ; 106 : 180 – 8 .

 American Academy of Pediatrics, American College of Obstetricians and Gynecologists . Guidelines for perinatal care . 8th ed . Elk Grove Village (IL) : AAP ; Washington, DC : American College of Obstetricians and Gynecologists ; 2017 .

 American College of Obstetricians and Gynecologists . Update on seafood consumption during pregnancy. ACOG Practice Advisory . Washington, DC : American College of Obstetricians and Gynecologists ; 2017 . Available at: https://www.acog.org/Clinical-Guidance-and-Publications/Practice-Advisories/ACOG-Practice-Advisory-Seafood-Consumption-During-Pregnancy . Retrieved June 20, 2018.

 Yu Z , Han S , Zhu J , Sun X , Ji C , Guo X . Pre-pregnancy body mass index in relation to infant birth weight and offspring overweight/obesity: a systematic review and meta-analysis . PLoS One 2013 ; 8 : e61627 .

 Copyright 2018 by the American College of Obstetricians and Gynecologists. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, posted on the Internet, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without prior written permission from the publisher.

 This information is designed as an educational resource to aid clinicians in providing obstetric and gynecologic care, and use of this information is voluntary. This information should not be considered as inclusive of all proper treatments or methods of care or as a statement of the standard of care. It is not intended to substitute for the independent professional judgment of the treating clinician. Variations in practice may be warranted when, in the reasonable judgment of the treating clinician, such course of action is indicated by the condition of the patient, limitations of available resources, or advances in knowledge or technology. The American College of Obstetricians and Gynecologists reviews its publications regularly; however, its publications may not reflect the most recent evidence. Any updates to this document can be found on www.acog.org or by calling the ACOG Resource Center.

 While ACOG makes every effort to present accurate and reliable information, this publication is provided "as is" without any warranty of accuracy, reliability, or otherwise, either express or implied. ACOG does not guarantee, warrant, or endorse the products or services of any firm, organization, or person. Neither ACOG nor its officers, directors, members, employees, or agents will be liable for any loss, damage, or claim with respect to any liabilities, including direct, special, indirect, or consequential damages, incurred in connection with this publication or reliance on the information presented.

 All ACOG committee members and authors have submitted a conflict of interest disclosure statement related to this published product. Any potential conflicts have been considered and managed in accordance with ACOG's Conflict of Interest Disclosure Policy. The ACOG policies can be found on acog.org . For products jointly developed with other organizations, conflict of interest disclosures by representatives of the other organizations are addressed by those organizations. The American College of Obstetricians and Gynecologists has neither solicited nor accepted any commercial involvement in the development of the content of this published product.

 Maybe you’ve just gotten married and have vague plans to start your family in a couple of years. Maybe you have one child and think you’ll have a second with the same ease. Or maybe you’re just beginning to wonder why—after three months of trying (or six or eight)—you’re not yet pregnant. Whatever your situation, know this: If you want a baby, you can’t assume it will just happen. As you’re reading this, some six million women and their husbands are facing infertility. They’re wondering what they need to do next to become pregnant, frustrated that they didn’t realize sooner just how big an impact age or medical problems were going to have on their lives.

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